Lead enterprise security strategy, risk management, and compliance programs. Median salary in St. Louis: $230K/year. Data from BLS, O*NET, and H-1B disclosures.
Figures represent annual base salary in St. Louis, Missouri. Reviewed by SalaryOptics Editorial · How we calculate this →
Analysis derived from the salary, COL, tax, and labor-market figures above — specific to this role and city.
Chief Information Security Officer (CISO)s in St. Louis earn approximately 4% lower than the US national median for this role — a $10,000 discount on annual base salary. St. Louis's lower wage level partially reflects the area's cost-of-living index of 86 (US avg = 100).
Adjusted for St. Louis's cost-of-living index (86), the median Chief Information Security Officer (CISO) salary buys the equivalent of $267,442 in a US-average-cost city. That's $27,442 more purchasing power than the national median — a meaningful real-wage advantage.
This role's national salaries are growing at 8.5% year-over-year, well above the BLS all-occupations average of ~3.5%. If that pace holds, the St. Louis median reaches $345,841 in five years.
Based on BLS 2022–2032 Employment Projections and WEF Future of Jobs Report 2026. At current growth rates, median salary reaches $230K by 2030.
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The median Chief Information Security Officer (CISO) salary in St. Louis, MO is $230,000 per year as of Q1 2026. This figure represents the midpoint of all reported compensation for this role in the St. Louis–MO metropolitan area, based on data from the Bureau of Labor Statistics Occupational Employment Statistics, H-1B visa disclosures from the Department of Labor, and O*NET occupational data.
Entry-level Chief Information Security Officer (CISO)s in St. Louis with 0–2 years of experience typically earn between $173,000 and $230,000 annually. Mid-career professionals with 3–7 years command $230,000 to $298,000, while senior-level practitioners with 8+ years of experience regularly earn $298,000 to $384,000 or more.
St. Louis has a cost of living index of 86 compared to the US national average of 100. This means your salary goes approximately 14% further in St. Louis than the national average. Missouri has a 5.3% state income tax rate.
Bachelor's in CS or Security; CISSP required. This role is 55% remote-eligible nationally, which can significantly expand the job market for St. Louis-based professionals.